Endocrine Abstracts

In terms of mechanism by which thyroid diseases lead the endothelial dysfunction, several aspects have been taking into consideration. One potential factor may be variation in plasma asymmetric dimethylarginine (ADMA) levels. ADMA, which is derived from the catabolism of proteins containing methylated arginine residues, competitively inhibits NOS. The relationship between thyroid disease and variation in plasma ADMA levels is still a potential research area. The aim of this st...

Introduction: In this study, we aimed to evaluate the effects of fat distribution and some adipokines on insulin resistance (IR) in prediabetic patients.Materials and Methods: cases were divided into three groups according to 75 gr-oral glucose tolerance test (OGTT) results [27 cases impaired fasting glucose (IFG), 36 cases impaired glucose tolerance (IGT) and 24 healthy control subjects]. Serum fasting insulin levels and lipid parameters were measured. ...

Diabetes mellitus (DM) includes a group of carbohydrate metabolism disorders that is characterized by hyperglycemia and leads long-term macro- and microvascular complications. Also siblings of type 2 diabetic patients have increased relative risk of micro and macrovasculer outcome of DM even though their plasma glucose levels in normal range. Genetically determined hyperinsulinemia, insulin resistance and associated dyslipidemia have crucial role in the processes of vascular a...

Accelerated coronary and peripheral vascular atherosclerosis is one of the most common and chronic complications of diabetes mellitus. A relatively recently analysed aspect of coronary artery disease in this condition is its silent nature. We studied silent myocardial ischaemia (SMI) in unselected consecutive middle aged asymptomatic patients with type II diabetes by treadmill exercise test.Ninety four asymptomatic type II diabetics between the ages 36 a...